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My name is Neville Pettersson and liverbasics.com is my site. The aim is to demystify the often complicated human liver.
The classic liver transplant involves use of a whole liver from a deceased donor. This is still the most common form of the operation. However, new methods include "living donor" liver transplantation. In this procedure, the entire liver of the patient is removed, but it is replaced with only a piece of the donor liver. A healthy liver has remarkable regenerative properties, and the donor's liver normally regenerates within 4 to 6 weeks. The transplanted portion in the recipient also regenerates to full capacity. This greatly increases the availability of donors.
End stage liver disease, as the name implies, is the final stage of a progressive
liver condition, such as cirrhosis of the liver, progressive hepatitis (e.g. viral
hepatitis type C), or liver cancer. The ICD 9 code for end stage liver disease is
End stage liver disease is a condition in which liver function is largely or entirely lost. It is a terminal condition unless a liver transplant is performed.
The Model for End-
The score uses values for serum bilirubin, serum creatinine, and the international
normalized ratio for prothrombin time (INR) to generate a single numerical score
used to predict mortality from liver disease. Certain tweak factors occur with a
diagnosis of liver cancer and when the patient has undergone repeated dialysis.
Unlike earlier stages of liver disease, end stage liver disease always causes overt symptoms. These include pain in various parts of the body, usually including pain in the upper abdominal cavity over the liver itself, but pains can occur in other areas, too. The liver is usually inflamed and, depending on the underlying cause of the liver failure, may present with scar tissue. Other symptoms include jaundice, dark-
One fairly common complication is hepatic encephalopathy. This is a condition of reduced brain function resulting from the buildup of toxins in the bloodstream due to failure of liver function. Symptoms are often severe, and can include loss of consciousness, changes in behavior, impaired judgment, drowsiness, slurred speech, confusion, disorientation, eventually leading the patient to lapse into a coma. Sufferers from hepatic encephalopathy who become comatose die about 80 percent of the time.
Another complication is portal hypertension. This is caused by the inflammation and build-
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